Fish sauce is difficult to substitute precisely because it does several things at once: it salts, it adds umami, and it adds a faint oceanic quality that is the backbone of Southeast Asian cooking. No single substitute replicates all three, but for most cooking contexts, you need only two of those three - and there is a substitute that covers them.
The closest general-purpose substitute. Soy sauce delivers umami (from fermented soybeans rather than fish) and salinity in roughly similar quantities to fish sauce. It lacks the oceanic quality and is slightly less complex, but in most cooked dishes - stir-fries, marinades, braises - the difference is minor.
Made from fermented coconut palm sap, coconut aminos are sweeter and lower in sodium than soy sauce or fish sauce. They work well for people avoiding soy, and their sweetness can be an advantage in dressings and marinades. The umami depth is noticeably lower.
Miso is a paste rather than a liquid, so it requires dilution or integration into a sauce. But it is arguably the most flavour-complex substitute for fish sauce in slow-cooked dishes, because aged miso carries a similar depth of fermented protein breakdown. White miso is mildest; red miso is closest in intensity to fish sauce.
Worcestershire contains fermented anchovies, tamarind, and vinegar - it is actually a fermented umami sauce in its own right. The flavour profile is more complex and more acidic than fish sauce, with a slightly sweet note from the tamarind. Works well in Western cooking where fish sauce appears in adapted recipes.
If you have made your own fish garum (see the garum from scratch guide), it is the most direct fish sauce substitute because it is essentially the same product. The flavour is typically more complex and less salty than commercial fish sauce, so start with slightly more than the recipe calls for and taste as you go.
For a completely plant-based substitute that approximates the oceanic umami of fish sauce:
For more on the broader world of fermented umami condiments and how they compare, see the Complete Guide to Garum and Fermented Umami Sauces.